Pathogenesis of Simian Immunodeficiency Virus-Induced Alterations in Macaque Trigeminal Ganglia
نویسندگان
چکیده
منابع مشابه
Pathogenesis of simian immunodeficiency virus-induced alterations in macaque trigeminal ganglia.
Peripheral neuropathy is the most frequent neurologic complication associated with human immunodeficiency virus (HIV) infection, yet its pathogenesis remains poorly understood. To study the mechanisms causing HIV-induced peripheral nervous system disease, we examined trigeminal ganglia obtained from simian immunodeficiency virus (SIV)-inoculated macaques. SIV-infected macaques developed multifo...
متن کاملNeuropathogenesis of simian immunodeficiency virus infection in macaque monkeys.
Patients infected with human immunodeficiency virus (HIV) develop immunologic dysfunction and multiorgan inflammatory diseases directly associated with HIV-1 infection. Of these inflammatory diseases, the most devastating to the HIV-infected patient is involvement of the central nervous system (CNS). The pathogenesis of the clinical syndrome observed in these patients, termed HIV-associated dem...
متن کاملUnraveling the pathogenesis of HIV peripheral neuropathy: insights from a simian immunodeficiency virus macaque model.
Peripheral neuropathy (PN) is the most frequent neurologic complication in individuals infected with human immunodeficiency virus (HIV). It affects over one third of infected patients, including those receiving effective combination antiretroviral therapy. The pathogenesis of HIV-associated peripheral neuropathy (HIV-PN) remains poorly understood. Clinical studies are complicated because both H...
متن کاملElectrostatic Potential of Human Immunodeficiency Virus Type 2 and Rhesus Macaque Simian Immunodeficiency Virus Capsid Proteins
Human immunodeficiency virus type 2 (HIV-2) and simian immunodeficiency virus isolated from a macaque monkey (SIVmac) are assumed to have originated from simian immunodeficiency virus isolated from sooty mangabey (SIVsm). Despite their close similarity in genome structure, HIV-2 and SIVmac show different sensitivities to TRIM5α, a host restriction factor against retroviruses. The replication of...
متن کاملPathogenesis of simian immunodeficiency virus encephalitis: viral determinants of neurovirulence.
To examine the relationship between macrophage tropism and neurovirulence, macaques were inoculated with two recombinant hybrid viruses derived from the parent viruses SIVmac239, a lymphocyte-tropic, non-neurovirulent clone, and SIV/17E-Br, a macrophage-tropic, neurovirulent virus strain. The first recombinant, SIV/17E-Cl, contained the portion of the env gene that encodes the surface glycoprot...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuropathology and Experimental Neurology
سال: 2007
ISSN: 0022-3069
DOI: 10.1097/nen.0b013e31802c398d